01 - In a small bowl, whisk together the salt, black pepper, smoked paprika, garlic powder, and onion powder until evenly combined.
02 - Pat the tilapia fillets thoroughly dry with paper towels. Sprinkle both sides of each fillet evenly with the seasoning blend, pressing gently so the spices adhere.
03 - For a crispier crust, lightly dredge each seasoned fillet in cornmeal or gluten-free flour, shaking off any excess.
04 - Heat the olive oil or butter in a large nonstick skillet over medium-high heat until the oil shimmers and a drop of water sizzles on contact.
05 - Carefully place the fillets in the hot skillet, working in batches if necessary to avoid crowding. Cook for 3 to 4 minutes on the first side until the underside is golden brown and the fish releases easily from the pan.
06 - Gently flip each fillet using a fish spatula and cook for another 2 to 3 minutes until the fish is completely opaque and flakes easily when tested with a fork.
07 - Transfer the fillets to serving plates immediately and garnish with fresh lemon wedges. Squeeze lemon juice over the fish just before eating.